Omega 3 Fatty Acids | A Metabolic Plan

Are Your "Energy Factories" Producing?

Filed under: health and nutrition; Tagged as: acetyl-L-carnitine, amino acid, brain, brain health, cellular energy, energy, fatigue, headaches, health, heart disease, L-carnitine, memory, Omega 3 fatty acids

As we age, the metabolic activity in our cells decreases which means less energy. Cellular energy is produced by transporting stored fat through the cell membrane and into the mitochondria within the cell, where the fats are oxidized. Overtime cellular debris builds up from the oxidation and less energy is produced. Since energy is necessary for the proper functioning of all our organs, they too are affected by a slowing in our “energy factories“.

Acetyl-L-carnitine (ALC) is the biologically active form of the amino acid, L-carnitine, which aids the body in the production of energy and has been shown to protect cells throughout the body against age-related degeneration. Most clinical research has focused on the brain, where improved mood, memory and cognition have been observed in response to ALC. A new study shows that ALC helps maintain normal blood flow in the brain by maintaining the cell’s energy cycle. As people grow older, circulation to the brain diminishes which may cause fatigue, reduced drive, faintness, dizziness, headaches, as well as deficits in attention and memory. Acetyl-L-carnitine appears to protect against some of the known negative effects that aging induces in the brain. There is a study that even suggests that ALC might someday be used in hospital emergency rooms and stroke recovery centers to improve the prognosis of patients (with thrombotic or embolic stroke) who are often given little hope of full recovery. Acetyl-L-carnitine may also facilitate nerve regeneration after nerve injury.

However, reports on ALC for the treatment of Alzheimer’s disease have been contradictory. Some studies show encouraging signs, while other studies show no benefit. A placebo-controlled study at Stanford University School of Medicine in California showed that Alzheimer’s disease patients under age 62 benefited more from ALC than older patients. The doctors concluded that acetyl-L-carnitine slows the progression of Alzheimer’s disease in younger subjects. Though this is an important study, Alzheimer’s patients over 61 may want to still consider ALC for its other known neurological benefits, which were not included in this particular study.

Published research shows ALC is critical to youthful cellular function in the brain, heart, liver, peripheral nerve and immune system as well helping in prevention of cataracts. Supplementation with ALC becomes an even greater consideration when we realize the potential anti-aging effects this amino acid may produce when taken in combination with CoQ10 and alpha lipoic acid.

When sugars bind with protein(called glycation), it forms most notably in the lens of the eye (cataract), the brain (senility) and the collagen of the skin. Scientists recently evaluated the effects of acetyl-L-carnitine on the glycation of lens proteins. The results show that ALC suppresses glycation by 42%, thus lowering the risk of cataracts.

There have been studies focusing on respiration rates in the heart mitochondria of rats. Older rats had a 40% lower rate of respiration and cell energy. But when they received acetyl-L-carnitine, their heart rates were almost entirely restored to a more youthful rate. Acetyl-L-carnitine has actually been used in treating congestive heart failure in humans, as well.

While research is ongoing, there are certainly indications that supplementing with Acetyl-L-carnitine, alpha lipoic acid and CoQ10 is beneficial in aiding our “energy factories” to produce efficiently. This, in turn, keeps many organs functioning at a more youthful level.

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Continuing on the subject of inflammation there is more and more evidence that the risk of heart disease and/or diabetes can be greatly reduced by lowering inflammation.

Are you at high risk for heart disease or diabetes? During your yearly blood work, note the level of CRP (C-reactive Protein). This is a measure of hidden inflammation – it shows if there is inflammation active in your blood vessels, for instance. If the levels of CRP are high (>3.0 mg/L) the risk of a heart attack can double or triple. This is something you need to discuss with your doctor to understand what your individual risk is.

There are, however, several lifestyle changes one can make if you are at high risk and everyone should follow as a matter of staying healthy.

Exercise: 30-60 minutes/day has been shown in studies to significantly reduce inflammation – this should include aerobic as well as strength training.
Weight loss improves insulin response and lowers inflammation.
Eating Healthy – one diet that seems to be an overall diet to follow is the Mediterranean diet. It is primarily fresh fruits and vegetables, olive oil, nuts and fish with basically no processed foods.

Besides these three critical things to do, supplements of fish oil (Omega 3 fatty acids) and Vitamin D can greatly reduce inflammation as well as improve other important functions. There are many other supplements that have been found t o reduce inflammation as well, such as DHEA, chromium, white bean extract, magnesium and flavinoids. Flavinoids are found in green tea, dark chocolate, apples and cinnamon as well as red wine which contains resveratrol.

Start making small changes in your lifestyle now and you will over time make large changes in the quality of life you will experience. Of course, you should discuss with your doctor the changes you are making as you may have special needs.